Omega-3 fatty acids have long been associated with heart health. On August 19th, the American Heart Association (AHA) released a new advisory highlighting the benefits of prescription omega-3s in lowering triglyceride levels. According to recent clinical trials, omega-3 fatty acid medications can reduce triglycerides by 20–30% in most patients who require treatment.
Dr. Ann Skulas-Ray, lead author of the advisory, noted:
"From our review of 17 randomized clinical trials, we concluded that 4 grams daily of prescription omega-3s is both effective and safe when used with statins."
This advisory, published in the AHA’s Circulation journal, underscores omega-3's role in reducing cardiovascular risks through triglyceride management.
How Does Omega-3 Help the Heart?
Prescription omega-3s come in two main forms:
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EPA (eicosapentaenoic acid) only
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EPA and DHA (docosahexaenoic acid) combined
While there haven’t been direct comparisons between the two types at prescription levels, both are considered effective for reducing triglycerides and supporting cardiovascular health.
Some FDA-approved products include:
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Lovaza (EPA + DHA)
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Vascepa (EPA-only)
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Epanova (EPA + DHA, not currently available)
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Omtryg (similar to Lovaza, not currently available)
These medications are approved for managing very high triglyceride levels (≥500 mg/dL) and borderline high levels (150–199 mg/dL), which affect around 25% of U.S. adults.
Does Omega-3 Reduce Heart Rate and Cholesterol?
While omega-3s are not primarily prescribed to reduce heart rate, studies suggest they may have a modest effect in improving overall heart rhythm and lowering heart rate variability. Their main clinical role remains in lipid management.
The REDUCE-IT trial, which tested 4 grams/day of EPA-only in high-risk patients, found a 25% reduction in major cardiovascular events. Similarly, upcoming results from the STRENGTH trial aim to further validate omega-3's cardiovascular benefits.
Key Omega-3 Benefits for Heart Health
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Reduces triglycerides
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May lower non-HDL cholesterol and ApoB
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Decreases cardiovascular risk when combined with statins
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Safe and effective as monotherapy or adjunct treatment
New Developments: Omega-3 and Blood Pressure
In June, the FDA approved a qualified health claim stating that EPA and DHA may help lower blood pressure, a major risk factor for coronary heart disease. However, the FDA also noted that the evidence remains inconsistent and inconclusive.
To make these claims, dietary supplements must contain at least 0.8 grams of EPA and DHA per serving.
Regional Omega-3 Deficiencies and Risk
A study across seven cities in the U.S. "stroke belt" (e.g., Memphis, Lexington, Jacksonville) revealed that 42% of participants had Omega-3 Index scores below 4%, indicating significantly higher risk for sudden cardiac death.
According to Dr. Bill Harris:
"Low Omega-3 Index levels may explain the higher rates of cardiovascular disease in these regions."
Omega-3s and Aortic Calcification
Another study from Japan published in Nutrition, Metabolism & Cardiovascular Diseases examined over 1,000 men aged 40–49. The findings revealed a strong inverse relationship between DHA and aortic calcification, meaning higher DHA levels were associated with less calcium buildup in arteries.
This suggests omega-3s may protect the heart not only by improving lipids but also by preventing structural damage to arteries.
Foods with Omega-3: Natural Sources for a Healthy Heart
Incorporating omega-3 rich foods into your diet is a great way to support cardiovascular health. Some top dietary sources include:
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Fatty fish (salmon, mackerel, sardines, anchovies)
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Chia seeds
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Flaxseeds
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Walnuts
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Algae-based supplements (for vegetarians and vegans)
Eating these regularly can naturally boost your Omega-3 Index and may reduce the need for medication in some individuals.
Omega-3 for Heart Protection
So, is omega-3 good for your heart? The answer is a resounding yes. From reducing triglycerides and blood pressure to potentially lowering heart rate and preventing arterial calcification, omega-3s are powerful allies in cardiovascular wellness.
If you’re at risk of high triglycerides or heart disease, talk to your doctor about whether omega-3 for heart health—either through diet or prescription—might be right for you.
Credit: OmegaQuant Website
